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Roger Linington

College positions:
Visiting Fellow
Simon Fraser University
Contact details:

Professor Roger Linington

Roger Linington is a Professor and Tier I Canada Research Chair in Natural Products and High-Throughput Screening in the Department of Chemistry at Simon Fraser University.

Professor Linington received his B.Sc. in Chemistry from the University of Leeds in the UK, his Ph.D. from the University of British Columbia in Vancouver Canada under the supervision of Prof. Raymond Andersen, and postdoctoral work with Prof. William Gerwick at the Scripps Institution of Oceanography at UCSD where he was a participating member of the Panama ICBG project. During this time, he lived and worked in Panama City, Panama, running a semi-independent marine natural products drug discovery program. From 2007 to 2015 he was a faculty member at the University of California Santa Cruz in the Department of Chemistry and Biochemistry. Since 2015 he has been based in the Department of Chemistry at Simon Fraser University in Vancouver, Canada where he is a Professor and Tier I Canada Research Chair in Natural Products and High-Throughput Screening. He is the recipient of several awards, including the 2020 IntelliSyn Pharma Research Excellence Award. He has published over 105 manuscripts, and his research program focuses on designing new screening, analytical, and informatics methods for drug discovery and development of natural products.

Select publications

  • Liu, D. Y.; Phillips, L.; Wilson, D. M.; Fulton, K. M.; Twine, S. M.; Wong, A.; Linington, R. G.* “Collateral Sensitivity Profiling in Drug-Resistant Escherichia coli Identifies Natural Products Suppressing Cephalosporin Resistance”, Nature Communications, 2023, 14, 1976. doi: 10.1038/s41467-023-37624-4.
  • Morehouse, N. J.; Clark, T. N.; McMann, E. J. ;van Santen, J. A.; Haeckl, F. P. J.; Gray, C. A.; Linington, R. G.* “Annotation of Natural Product Compound Families Using Molecular Networking Topology and Structural Similarity Fingerprinting”, Nature Communications, 2023, 14, 308. doi: 10.1038/s41467-022-35734-z.
  • Hight, S. K.‡; Clark, T. N.‡; Kurita, K. L.; McMillan, E. A.; Bray, W.; Shaikh, A. F.; Khadilkar, A.; Haeckl, F. P. J.; Carnevale-Neto, F.; La, S. Lohith, A.; Vadena, R. M.; Lee, J.; Wei, S.; Lokey, R. S.; White, M. A.*; Linington, R. G.*; MacMillan, J. B.* “High-Throughput Functional Annotation of Natural Products by Integrated Activity Profiling”, Proceedings of the National Academy of Sciences, USA, 2022, 119, e2208458119. doi: 10.1073/pnas.2208458119.
  • Lee, S.; van Santen, J. A.; Farzaneh, N.; Liu, D. Y.; Pye, C. R.; Baumeister, T. U. H.; Wong, W.-R.; Linington, R. G.* “NP Analyst: An Open Online Platform for Compound Activity Mapping”, ACS Central Science, 2022, 8, 223-234. doi: 10.1021/acscentsci.1c01108.
  • McCaughey , C.S.; van Santen, J. A.; van der Hooft, J. J. J.; Medema, M. H.; Linington, R. G.* “An Isotopic Labeling Approach Linking Natural Products with Biosynthetic Gene Clusters.”, Nature Chemical Biology, 2022, 18, 295–304. doi: 10.1038/s41589-021-00949-6.
  • van Santen, J. A.; Poynton, E. F.; Iskakova, D.; McMann, E.; Alsup, T. A.; Clark, T. N.; Fergusson, C. H.; Fewer, D. P.; Hughes, A. H.; McCadden, C. A.; Parra Villalobos, J.; Soldatou, S.; Rudolf, J. D.; Janssen, E. M.-L.; Duncan, K. R.; Linington, R. G.* “The Natural Products Atlas 2.0: A Database of Microbially-Derived Natural Products”, Nucleic Acids Research, 2022, 50, D1317–D1323. doi: 10.1093/nar/gkab941.
  • Claesen, J.; Spagnolo, J. B.; Flores Ramos, S.; Kurita, K. L.; Byrd, A. L.; Aksenov, A. A.; Melnik, A. V.; Wong, W.-R.; Wang, S.; Hernandez, R. D.; Donia, M. S.; Dorrestein, P. C.; Kong, H. H.; Segre, J. A.; Linington, R. G.; Fischbach, M. A.*; Lemon, K. P.* “A Cutibacterium Acnes Antibiotic Modulates Human Skin Microbiota Composition in Hair Follicles”, Science Translational Medicine, 2020, 12, eaay5445. doi: 10.1126/scitranslmed.aay5445.

Select Awards

  • Tier I Canada Research Chair in Natural Products and High-Throughput Screening (2020 – 2027)
  • CIC Intellisyn Pharma Research Excellence Award (2020)
  • American Society of Pharmacognosy Matt Suffness Young Investigator Award (2014)

Further links

Lab website []