Subject: Computational Cancer Biology | Cellular Genetics | Neuroscience
Department/Institution: EMBL-EBI & Sanger Institute, Cambridge, UK
Jun Sung Park (a.k.a Jun) obtained his BSc in Biological Sciences at KAIST (Korea Advanced Institute of Science and Technology) and continued his PhD study under supervision of Professor Jeong Ho Lee. While trained as a hybrid experimental-computational biologist, he detected and functionally validated sub-clonal (somatic) mutations in brain tissues underlying idiopathic brain diseases, such as Alzheimer's disease, glioblastoma and intractable epilepsy. He gradually anticipated that, however, it is not only the mutation carrying cells, but understanding spatial information and related cell-to-cell interaction are crucial to unravel profound pathophysiology of diseases.
Recent technological advances in spatially resolved RNA-sequencing and high-multiplexed RNA imaging (STx) have pioneered the spatial transcriptomic analysis of tissues. As an ESPOD fellow (shared with EMBL-EBI and Sanger Institute), Jun aims to combine single cell and STx data to enable large-scale spatial genomic cancer studies. His particular research interest involves understanding the tumour micro-evnironment and subsequent metastatic event in uveal melanoma, role of myeloid-derived suppressor cells in lung carcinoma and clonal evolution in breast invasive ductal carcinoma.
Lee, Joo Ho, Jeong Eun Lee, Jee Ye Kahng, Se Hoon Kim, Jun Sung Park, Seon Jin Yoon, Ji-Yong Um, et al. 2018. “Human Glioblastoma Arises from Subventricular Zone Cells with Low-Level Driver Mutations.” Nature 560 (7717): 243–47.
Park, Jun Sung, Junehawk Lee, Eun Sun Jung, Myeong-Heui Kim, Il Bin Kim, Hyeonju Son, Sangwoo Kim, et al. 2019. “Brain Somatic Mutations Observed in Alzheimer’s Disease Associated with Aging and Dysregulation of Tau Phosphorylation.” Nature Communications 10 (1): 3090.
Park, Sun Ah, Jin Myung Jung, Jun Sung Park, Jeong Ho Lee, Bumhee Park, Hyung Jun Kim, Jeong-Ho Park, et al. 2020. “SWATH-MS Analysis of Cerebrospinal Fluid to Generate a Robust Battery of Biomarkers for Alzheimer’s Disease.” Scientific Reports 10 (1): 7423.
Ju, Younghee, Jun Sung Park, Daejeong Kim, Bumsoo Kim, Jeong Ho Lee, Yoonkey Nam, Han-Wook Yoo, Beom Hee Lee, and Yong-Mahn Han. 2020. “SHP2 Mutations Induce Precocious Gliogenesis of Noonan Syndrome-Derived IPSCs during Neural Development in Vitro.” Stem Cell Research & Therapy 11 (1): 209.
Kim, Myeong-Heui, Il Bin Kim, Junehawk Lee, Do Hyeon Cha, Sang Min Park, Ja Hye Kim, Ryunhee Kim, et al. 2021. “Low-Level Brain Somatic Mutations Are Implicated in Schizophrenia.” Biological Psychiatry 90 (1): 35–46.
Young, Adam M. H., Natsuhiko Kumasaka, Fiona Calvert, Timothy R. Hammond, Andrew Knights, Nikolaos Panousis, Jun Sung Park, et al. 2021. “A Map of Transcriptional Heterogeneity and Regulatory Variation in Human Microglia.” Nature Genetics 53 (6): 861–68.
Kleshchevnikov, V., A. Shmatko, E. Dann, et al. 2020. “Comprehensive Mapping of Tissue Cell Architecture via Integrated Single Cell and Spatial Transcriptomics.” BioRxiv. https://www.biorxiv.org/content/10.1101/2020.11.15.378125v1.abstract.
Gataric, Milana, Jun Sung Park, Tong Li, Vasy Vaskivskyi, Jessica Svedlund, Carina Strell, Kenny Roberts, et al. 2021. “PoSTcode: Probabilistic Image-Based Spatial Transcriptomics Decoder.” https://europepmc.org/article/ppr/ppr407242.
Lomakin, A., J. Svedlund, C. Strell, M. Gataric, et al. 2021. “Spatial Genomics Maps the Structure, Character and Evolution of Cancer Clones.” BioRxiv. https://www.biorxiv.org/content/10.1101/2021.04.16.439912v1.abstract.