Dr Gianluca Amadei

Dr Gianluca Amadei completed his PhD at the University of Toronto in 2016, under the supervision of Dr Freda Miller, where he studied the role of RNA-binding proteins in the context of mammalian embryonic brain development. Immediately after graduation he moved to Cambridge to join the research group of Professor Magdalena Zernicka-Goetz in the Department of Physiology, Development and Neuroscience where he studies modelling of mammalian development using stem cells.

Selected publications:

Amadei G, Lau KYC, De Jonghe J, Gantner CW, Sozen B, Chan C, Zhu M, Kyprianou C, Hollfelder F, Zernicka-Goetz M. Inducible Stem-Cell-Derived Embryos Capture Mouse Morphogenetic Events In Vitro. Dev Cell. 2021 Feb 8;56(3):366-382.e9. doi: 10.1016/j.devcel.2020.12.004. Epub 2020 Dec 29. PMID: 33378662.

Sozen B, Amadei G, Cox A, Wang R, Na E, Czukiewska S, Chappell L, Voet T, Michel G, Jing N, Glover DM, Zernicka-Goetz M. Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures. Nat Cell Biol. 2018 Aug;20(8):979-989. doi: 10.1038/s41556-018-0147-7. Epub 2018 Jul 23. Erratum in: Nat Cell Biol. 2018 Oct;20(10):1229. PMID: 30038254.

Amadei G, Zander MA, Yang G, Dumelie JG, Vessey JP, Lipshitz HD, Smibert CA, Kaplan DR, Miller FD. A Smaug2-Based Translational Repression Complex Determines the Balance between Precursor Maintenance versus Differentiation during Mammalian Neurogenesis. J Neurosci. 2015 Nov 25;35(47):15666-81. doi: 10.1523/JNEUROSCI.2172-15.2015. PMID: 26609159; PMCID: PMC6705466.

Vessey JP, Amadei G, Burns SE, Kiebler MA, Kaplan DR, Miller FD. An asymmetrically localized Staufen2-dependent RNA complex regulates maintenance of mammalian neural stem cells. Cell Stem Cell. 2012 Oct 5;11(4):517-28. doi: 10.1016/j.stem.2012.06.010. Epub 2012 Aug 16. PMID: 22902294.