Professor William Hancock
Will Hancock is a Professor of Biomedical Engineering and Chemistry at Pennsylvania State University, and who will be spending his Fall 2026 sabbatical at the MRC Laboratory of Molecule Biology (LMB). He studies the molecular motors that transport cargo like vesicles, organelles and chromosomes throughout cells, as well as the microtubule tracks that they move along. This transport is important in neurons and in dividing cells, and his work links to both neurodegenerative disease and to developing approaches for targeting fast-dividing cancer cells. Hancock’s perspective on biology is to consider cells as collections of molecular machines that orchestrate their activities to carry out crucial cellular functions. This perspective leads to an interdisciplinary approach that integrates biophysics, cell biology, computational modeling, microscopy, and materials science. He also works on understanding cellulase enzymes that break down cellulose and a newly discovered class of enzymes called PETases that degrade plastic and have the potential to address both plastics pollution and the buildup of micro- and nanoplastics in our bodies.
Hancock is passionate about graduate training, and he runs an NIH-funded training grant at Penn State titled Molecular Machines Mechanism and Structure. This sabbatical will be an opportunity to share notes and best practices with international colleagues. He is an enthusiast of the enneagram, a personal growth tool that describes nine personality types and provides paths for better self-awareness and for improving interpersonal relationships, and his long-term goal is to use the enneagram to improve graduate mentorship and mentor-mentee relationships, a critical need in academic science and engineering. He is married and has two children in their 20s, and in his spare time he likes to play guitar and golf.
Select publications
- Bidirectional cargo transport: moving beyond tug of war. W.O. Hancock. 2014. Nat Rev Mol Cell Biol. 15(9):615-28. PMID: 25118718
- The kinesin-1 chemomechanical cycle: stepping toward a consensus. 2016. W.O. Hancock. Biophys J, 110(6): 1216-1225. doi: 10.1016/j.bpj.2016.02.025. PMID: 27028632
- Kinesin-1, -2, and -3 motors use family-specific mechanochemical strategies to effectively compete with dynein during bidirectional transport. Gicking, A.M., T.C. Ma, Q. Feng, R. Jiang, S. Badieyan, M.A. Cianfrocco, and W.O. Hancock. 2022. eLife 11:e82228. PMID: 36125250
- Direct observation of individual tubulin dimers binding to growing microtubules. K.J. Mickolajczyk, E.A. Geyer, T. Kim, L.M. Rice, and W.O. Hancock. 2019. Proc Natl Acad Sci U S A 116:7314-7322. PMID: 30804205
- Kinetics of nucleotide-dependent structural transitions in the kinesin-1 hydrolysis cycle. 2015. K.J. Mickolajczyk, N.C. Deffenbaugh, J. Ortega Arroyo, J. Andrecka, P. Kukura, and W.O. Hancock. Proc. Natl. Acad. Sci., 112:E7186-7193. PMID: 26676576
- Nanoscale dynamics of cellulose digestion by the cellobiohydrolase TrCel7A. Z.K. Haviland, D. Nong, K.L.V. Kuntz, T.J. Starr, D. Ma, M. Tien, C.T. Anderson and W.O. Hancock. 2021. J. Biol. Chem. 297(3):101029. PMID: 34339742
- Measuring PETase enzyme kinetics by single-molecule microscopy. Zhang, Y. and W.O. Hancock. 2024. Biophysl J 123:3669-3677. PMID: 39300753
Select awards
- Dean’s Fellow, College of Engineering, Pennsylvania State University
- Fellow of American Institute for Medical and Biological Engineering
- First Place, Cell Slam, American Society for Cell Biology National Meeting, Philadelphia, PA, 2014
- Ally, PSU College of Engineering Center for Outreach and Inclusion
Further links
Hancock Lab: https://sites.psu.edu/hancocklab/
Google Scholar Profile: https://scholar.google.com/citations?user=99h5uxsAAAAJ&hl=en