Dr Christelle Langley
Dr Christelle Langley is a Cognitive Neuroscientist, she received her PhD from the University of Bristol in 2019. Her PhD focused on understanding the relationship between fatigue and cognition in Multiple Sclerosis, with particular emphasis on the neural mechanisms. She joined the University of Cambridge Department of Psychiatry in Professor Barbara J Sahakian’s lab in early 2019. She has since been involved in a number of projects and is gaining a national and international reputation in the fields of cognitive neuroscience, neuropsychology, psychiatry and psychopharmacology. She has a number of peer reviewed publications in high quality journals such as the Lancet Neurology, the Journal of Neurology, Neurosurgery and Psychiatry, Psychological Medicine and Neuropsychopharmacology. Google Scholar credits her with an h-index of 14 and 615 citations.
In collaboration with Professor Sarah Tabrizi at the University College London she has been examining cognitive function in a group of very far from onset premanifest Huntington’s disease patients (Young Adult Study – YAS). Dr Langley has also been working with Professor Fabio Cuzzolin to examine the importance of Theory of Mind in artificial intelligence (AI) models. In collaboration with Professor Gitte Moos Knudsen at the University of Copenhagen Dr Langley conducted an experimental medicine study examining the effects of three-week escitalopram administration on a wide range of cognitive functions, particularly reward learning in healthy volunteers, including MRI. Together with Professor Graham Murray she has a key role within the Office of Life Sciences / NIHR flagship Mental Health Mission project. Dr Langley has an advisory role in the Centre for Lifelong Learning project which is a joint research venture with Nanyang Technological University. Dr Langley has established research connections with Fudan University and is the Coordinator for the Cambridge-Fudan Initiative in the Department of Psychiatry.
Select publications
- Scahill, R. I., Zeun, P., Osborne-Crowley, K., Johnson, E. B., Gregory, S., Parker, C., Lowe, J., Nair, A., O’Callaghan, C., Langley, C., … & Tabrizi, S. J. (2020). Biological and clinical characteristics of gene carriers far from predicted onset in the Huntington’s disease young adult study (HD-YAS): a cross-sectional analysis. The Lancet Neurology, 19(6), 502-512. https://doi.org/10.1016/S1474-4422(20)30143-5
- Langley, C., Gregory, S., Osborne-Crowley, K., O’Callaghan, C., Zeun, P., Lowe, J., … & Sahakian, B. J. (2021). Fronto-striatal circuits for cognitive flexibility in far from onset Huntington’s disease: evidence from the Young Adult Study. Journal of Neurology, Neurosurgery & Psychiatry, 92(2), 143-149. http://dx.doi.org/10.1136/jnnp-2020-324104
- Langley, C., Selamoglu, A., Crean, R., Savulich, G., Cormack, F., Sahakian, B. J., & Mason, B. (2021). Neuropsychological performance in young adults with cannabis use disorder. Journal of Psychopharmacology, 35(11), 1349-1355. https://doi.org/10.1177/02698811211050548
- Langley, C., Cirstea, B. I., Cuzzolin, F., & Sahakian, B. J. (2022). Theory of Mind and Preference Learning at the Interface of Cognitive Science, Neuroscience, and AI: A Review. Frontiers in Artificial Intelligence, 62. https://doi.org/10.3389/frai.2022.778852
- Langley, C., Armand, S., Luo, Q., Savulich, G., Segerber, T., Søndergaard, A., Pederson, E.B., Svart. N., Overgaard-Hansen, O., Johansen, A., Borgsted, C., Cardinal, R.N., Robbins, T.W., Stenbaek, D.S., Knudsen, G.M., and Sahakian, B.J. (2023). Chronic escitalopram in healthy volunteers has specific effects on reinforcement sensitivity: A double-blind, placebo-controlled semi-randomised study. Neuropsychopharmacology https://doi.org/10.1038/s41386-022-01523-x
- Langley, C., Masuda, N., Godwin, S., De Marco, G., Davies-Smith, A., Jones, R., Bruce, J., and Thai, NJ. (2023). Dysfunction of basal ganglia functional connectivity associated with subjective and cognitive fatigue in Multiple Sclerosis. Frontiers in Neuroscience. 17, 1194859. https://doi.org/10.3389/fnins.2023.1194859
