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Emma Hazelwood

College positions:
Affiliated Postdoctoral Member
Subject:
Cancer Evolution
Department/institution:
Early Cancer Institute, Department of Oncology, University of Cambridge
Contact details:
eh843@cam.ac.uk

Dr Emma Hazelwood

Dr Hazelwood is a Research Associate at the University of Cambridge, based in the Early Cancer Institute.

Her current research focuses on understanding how cancer evolves, with the goal of improving early detection and monitoring strategies. She also holds visiting and honorary positions at The Francis Crick Institute and the University of Bristol.

Dr Hazelwood completed her PhD in Integrative Cancer Epidemiology at the University of Bristol in 2024. Her doctoral research investigated the relationship between obesity and colorectal cancer risk, combining genetic epidemiology, clinical trials, and in vitro methods to uncover biological mechanisms and potential prevention strategies. She additionally holds an MSc in Biological Sciences from the University of Manchester and a BSc in Biology from the University of Sheffield.

Select publications

  • Hazelwood E, Vincent EE, Albanes D, Bishop DT, Le Marchand L, Ulrich CM, Peters U, Murphy G, Samadder NJ, Anderson L, Murphy N, Van Guelpen B*, Papadimitrou N*. Plasma ghrelin and risks of sex-specific, site-specific, and early-onset colorectal cancer: a Mendelian randomization analysis. (2024) Cancer Epidemiology, Biomarkers and Prevention https://doi.org/10.1158/1055-9965.epi-24-0926 *These authors contributed equally and are joint senior authors.
  • Legge DN, Stanko E, Holt AK, Bull CJ, Collard TJ, Kollareddy M, Bellamy J, Groves S, Ma EH, Hazelwood E, Qualtrough D, Amulic B, Malik K, Williams AC, Jones N, Vincent, EE. Identifying targetable metabolic
    dependencies across colorectal cancer progression. (2024) Molecular Metabolism
    https://doi.org/10.1016/j.molmet.2024.102037
  • Bull CJ*, Hazelwood E*, Legge DN, Corbin LJ, Richardson T, Lee M, Yarmolinsky J, Smith-Byrne K, Hughes DA, Johansson M, McConnachie A, Messow C-M, Welsh P, Taylor R, Lean MEJ, Sattar N, Murphy N, Gunter M, Timpson NJ, Vincent E. Impact of weight loss on cancer-related proteins in serum: results from a cluster randomised controlled trial of individuals with type 2 diabetes. (2024) eBioMedicine https://doi.org/10.1016/j.ebiom .2024.104977 *These authors contributed equally and are joint first authors.
  • Bull CJ*, Hazelwood E*, Bell JA, Tan V, Constantinescu A, Borges MC, Legge DN, Burrows K, Huyghe JR, Brenner H, Castellví-Bel S, Chan AT, Kweon S-S, Le Marchand L, Li L, Cheng I, Pai RK, Figueiredo JC, Murphy N, Gunter MJ, Timpson NJ, Vincent EE. Identifying metabolic features of colorectal cancer liability using Mendelian randomization. (2023) eLife https://doi.org/10.7554/elife.87894 *These authors contributed equally and are joint first authors.
  • Perez-Cornago A, Smith-Byrne K, Hazelwood E, Martin S, Frayling T, Lewis S, Martin RM, Yaghootkar H, Travis RC, Key TJ. Genetic predisposition to metabolically unfavourable adiposity and risk of aggressive prostate cancer: A Mendelian randomization analysis. (2023) Cancer Medicine https://doi.org/10.1002/cam4.6220
  • Hazelwood E, Sanderson E, Tan VY, Ruth KS, Frayling TM, Dimou N, Gunter MJ, Dossus L, Newton C, Ryan N, Pournaras DJ, O’Mara TA, Davey Smith G, Martin RM, Yarmolinsky J. Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis. (2022). BMC Medicine https://doi.org/10.1186/s12916-022-02322-3
  • Richardson TG, Crouch DJM, Power GM, Morales-Berstein F, Hazelwood E, Fang S, Cho Y, Inshaw JRJ, Robertson CC, Sidore C, Cucca F, Rich SS, Todd JA, Davey Smith G. Childhood body size directly increases type 1 diabetes risk based on a lifecourse Mendelian randomization approach. (2022) Nature Communications https://doi.org/10.1038/s41467-022-29932-y

Select awards

  • National Cancer Research Institute (NCRI) Award for outstanding research. 2021.
  • Medical Research Council Population and Systems Medicine Research Grant (Co-Investigator). The causal role of ketone bodies in obesity-associated disease prevention. 2024-2027.
  • World Cancer Research Fund International Regular Grant Programme (Co-Investigator). How does adiposity distribution influence risk of obesity-related cancers? – Exploring causality and mechanisms. 2024-2027.
  • Cancer Research UK Prevention & Population Research Committee Project Award (Co-Investigator). Does the biological response to ketogenesis influence colorectal cancer risk? – Exploring causality and mechanism. 2024-2027.

Further links

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