Dr Julie Qiaojin Lin
Dr Lin is a Sir Henry Wellcome Postdoctoral Fellow funded by the Wellcome Trust at the UK Dementia Research Institute (DRI) at the University of Cambridge, Department of Clinical Neurosciences and Department of Chemical Engineering and Biotechnology.
She is also a UK DRI Emerging Leader, studying splicing regulation and localised protein production in neurons and their contributions to neuronal health and death using advanced imaging and multi-omics approaches, with a particular focus on neurodegenerative diseases.
She received her PhD in 2018, supervised by Professor Christine Holt in the Department of Physiology, Development and Neuroscience. Her PhD work explored how RNA localisation and local protein synthesis jointly regulate RNA and protein compositions in long neuronal extensions, ‘axons’.
- Live imaging of RNA transport and translation in Xenopus retinal axons, Lin, J. Q., & Cioni, J. M., Axonal Transport, Methods in molecular biology. Humana, New York, 2431, 49-69 (2022).
- Axonal mRNA translation in neurological disorders, Lin, J. Q., van Tartwijk, F. W., & Holt, C. E., RNA biology, 1-26 (2020).
- Late endosomes act as mRNA translation platforms and sustain mitochondria in axons, Cioni, J. M., Lin, J. Q., Holtermann, A. V., Koppers, M., … & Holt, C. E., Cell,176(1-2), 56-72 (2019).
- FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-pi Interactions, Qamar, S., Wang, G., Randle, S. J., Ruggeri, F. S., Varela, J. A., Lin, J. Q., Phillips, E. C., … & St George-Hyslop, P., Cell, 173(3), 720-734.e15 (2018). Single Molecule Translation Imaging Visualizes the Dynamics of Local β-Actin Synthesis in Retinal Axons, Ströhl, F., Lin, J. Q., … Holt, C. E., & Kaminski, C. F., Scientific reports, 7(1), 709 (2017). ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function, Murakami, T., Qamar, S., Lin, J. Q., Schierle, G. S. K.*, … Holt, C. E., Vendruscolo, M., Kaminski, C. F., & St George-Hyslop, P., Neuron, 88(4), 678-690 (2015).