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Shelly Singh-Gryzbon

College positions:
Official Fellow
Biofluid Mechanics
Chemical Engineering and Biotechnology
Contact details:

Dr Shelly Singh-Gryzbon

Shelly is an Assistant Professor in the Department of Chemical Engineering and Biotechnology. Her work involves the application of fundamental engineering principles, such as fluid dynamics and structural mechanics, to solve clinically relevant problems.

Shelly uses computational modelling and simulation to discover mechanistic relationships for improved understanding of the development and progression of (cardio)vascular diseases, and inform on the design, development and/or optimisation of medical devices used to treat these diseases. One area that she is particularly excited by is the integration of digital twins, computational simulation and artificial intelligence for personalised treatment of the individual patient, thereby reducing the risk of commonly observed adverse effects and improving clinical outcomes.

Shelly has worked on problems involving aneurysms, stenosis, single ventricles (in pediatric patients), and heart valve diseases such as aortic valve stenosis, and mitral and tricuspid regurgitation. She has developed computational models to investigate the biomechanic and hemodynamic effects of various treatments, for instance, stent insertion, Fontan, and transcatheter heart valve replacements and percutaneous repair procedures.

Her work is multi-disciplinary and interdisciplinary, involving extensive collaborations with experts from engineering, physics, mathematics, computer science, radiologists, clinicians, surgeons, and many others.

Select publications

  • Hatoum, H., et al. “Predictive Model for Thrombus Formation after Valve Implantation”, Cardiovascular Engineering Technology, 12:576-588, 2021.
  • Wei, Z.A., et al. “An Anterior Anastomosis for the Modified Fontan Connection: A Hemodynamic Analysis”, Seminars in Thoracic and Cardiovascular Surgery, 33,3:816-823, 2021.
  • Singh-Gryzbon, S., et al. “Influence of Patient-Specific Characteristics on Transcatheter Heart Valve Neo-sinus Flow: an in silico study”, Annals of Biomedical Engineering, 48:2400-2411, 2020.
  • Singh-Gryzbon, S., et al. “Development of a Computational Method for Simulating Tricuspid Valve Dynamics”, Annals of Biomedical Engineering, 47(6): 1422-1434, 2019.
  • Singh-Gryzbon, S., et al. “Tricuspid Valve Annular Biomechanics: Interactions with and Implications for Transcatheter Devices”, Cardiovascular Engineering Technology, 10(2): 193-204, 2019.
  • Wei, Z.A. et al. “Computational Fluid Dynamics Assessment Associated with Transcatheter Heart Valve Prostheses: A Position Paper of the ISO Working Group”, Cardiovascular Engineering Technology, 9(3): 289-299, 2018.
  • Singh, S. et al. “Aortic Flow Patterns before and after Personalised External Aortic Root Support Implantation in Marfan Patients”, Journal of Biomechanics, 49(1): 100-111, 2016.

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