Dr Daniel Richter
Dr Daniel Richter currently is a Postdoctoral Researcher at the MRC Laboratory of Molecular Biology in Cambridge.
He obtained a BSc and MSc in Interdisciplinary Sciences at ETH Zurich in Switzerland, where he also obtained his PhD in Biology in 2024, working on the discovery and application of naturally occurring enzymes. He is interested in Bioinformatic-guided discovery of novel enzymology and works on the characterization and exploration of novel chemical reactions inspired by nature. His PhD work focused on the development of novel antimicrobial compounds through the utilization of newly discovered enzymes.
Select publications
- Vagstad, A.L., Lakis, E., Csizi, K.-S., Walls, W., Richter, D., Lee, K.S., Stocker, R., Gugger, M., Broderick, W.E.., Broderick, J., Reiher, M., Piel, J. Mechanistic insights into post-translational α-keto-β-amino acid formation by a radical S-adenosyl methionine peptide splicease. Angewandte Chemie International Edition. 2025, e202418054.
- Richter, D., Courvoisier-Clément, A., Vagstad, A.L., Magyari S., Piel, J. A structurally conserved helix enables leader-independent tyramine splicing of proteins. Chemical Science. 2024, 15, 16645-16650.
- Richter, D., Piel, J. Novel types of RiPP-modifying enzymes. Current Opinion in Chemical Biology. 2024, 80, 102463.
- Richter, D., Vagstad, A.L. A peptide dehydratase with core strength. Nature Chemical Biology. 2024, 20, 546-548.
- Richter, D., Lakis, E., Piel, J. Site-specific, biorthogonal protein labelling by tetrazine ligation using endogeneous β-amino acid dienophiles. Nature Chemistry. 2023, 15, 1422-1430.
- Scott, T.A., Verest, M., Farnung, J., Forneris, C.C., Robinson, S.L., Ji, X., Hubrich, F., Chepkirui, C., Richter, D., Huber, S., Rust, P., Streiff, A.B., Zhang, Q., Bode, J.W., Piel, J. Widespread microbial utilization of ribosomal β-amino acid-containing peptides and proteins. Chem. 2022, 8, 2659-2677.
Select awards
- 05/2024: Chemistry Travel Award, Swiss Chemical Society, Bern, Switzerland
- 04/2022: ETH Spark Award, Zurich, Switzerland
