Dr Ryuya Edahiro

Dr Ryuya Edahiro’s current research focuses on elucidating the pathogenesis of intractable autoimmune and respiratory diseases by integrating host genetics data with state-of-the-art single-cell omics technologies. After graduating from The University of Osaka School of Medicine, he spent six years in clinical practice in respiratory medicine and clinical immunology, while conducting a broad range of clinical research on respiratory diseases (Edahiro R et al. BMJ Open 2014, Intern Med 2019, Thorac Cancer 2019, PLoS One 2019, Lung Cancer 2020).

During his doctoral course, Dr Edahiro focused on human genomics in COVID-19, performing genome-wide association studies (GWAS) and integrating host genetics data with single-cell transcriptomics to uncover mechanisms underlying COVID-19 severity (Namkoong H and Edahiro R et al. Nature 2022; Edahiro R et al. Nat Genet 2023).

After his appointment as an Assistant Professor, he has constructed an immune cell single-cell atlas incorporating host genetics (both germline and somatic variants), plasma proteomics, and metagenomic data. Using this multimodal resource, Dr Edahiro projected multi-layered human omics data into single-cell space, revealing that immune cells are dynamically characterized by multiple omics profiles at single-cell resolution (Edahiro R et al. Nat Genet 2025). As a physician-scientist, he aims to bridge computational immunology with single-cell and spatial genomics to understand autoimmune pathogenesis and ultimately translate these insights into clinically meaningful advances.